Ultra City Smiths

Tom Waits

as The Narrator (voice)

Jimmi Simpson

as Detective David Mills (voice)

Da'Vine Joy Randolph

as Detective Gail Johnson (voice)

John C. Reilly

as Donovan Smith (voice)

Bebe Neuwirth

as Lady Andrea The Giant (voice)

Jason Mantzoukas

as Tim Snodgrass (voice)

Damon Herriman

as Street Hustler Boy (voice)

Melissa Villaseñor

as Sister Mary Margaret (voice)

Kurtwood Smith

as Carpenter K. Smith (voice)

Tim Heidecker

as Mayor Kevin De Maximum (voice)

Chris Conrad

as Detective Nico Onasis (voice)

Hana Mae Lee

as Christina Smalls (voice)

Alia Shawkat

as Little Grace (voice)

Julian Barratt

as The Most Dangerous Man in the World (voice)

Kristen Bell

as Donella Pecker (voice)

Luis Guzmán

as Rodrigo Smalls (voice)

Sunita Mani

as Detective Jaya Mukherjee (voice)

Caleb McLaughlin

as Trevor Johnson (voice)

Tim Meadows

as Jeff Thumb (voice)

Terry O'Quinn

as Captain Krieger (voice)

Dax Shepard

as Chris Pecker (voice)

Debra Winger

as Trish McSapphire (voice)