Isabel

Michelle Jenner

as Isabel I de Castilla

Rodolfo Sancho

as Fernando II de Aragón

Irene Escolar

as Juana I de Castilla

Raúl Mérida

as Felipe I de Castilla

Álvaro Monje

as Juan II de Portugal

Héctor Carballo

as Carlos VIII de Francia

Borja Luna

as Luis XII de Francia

Jorge Bosch

as Alejandro VI

Nacho Aldeguer

as César Borgia

Julio Manrique

as Cristóbal Colón

Eusebio Poncela

as Francisco Jiménez de Cisneros