Sioux City

Lou Diamond Phillips

as Jesse Rainfeather Goldman

Salli Richardson-Whitfield

as Jolene Buckley

Melinda Dillon

as Leah Goldman

Lise Cutter

as Allison

Bill Allen

as Dan Larkin

Apesanahkwat

as Clifford Rainfeather

John Dye

as Colin Adams

Gary Farmer

as Russell White

Ralph Waite

as Drew McDermott

Tantoo Cardinal

as Dawn Rainfeather

Michael Corbett

as Ray Dawes

Ronny Quintanar Jr.

as Little Jesse

Jim Great Elk Waters

as Redbow

Adam Roarke

as Douglas Goldman

Joseph Marcell

as Dr. Darryl Reichert

Earl Boen

as Andre

Van B. Poole

as Mr. Sandoval

Erik Stabenau

as Young McDermott

Cody Eagleboy

as Boy on Street

Seth Dillon

as Boy Being Inoculated

Shanti Kahn

as Leslie Baker

Ericka Bryce

as Trading Post Cashier (uncredited)