María Félix La Doña

Úrsula Pruneda

as Josefina Güereña Rosas

Ximena Romo

as María Félix Joven

Guillermo García Cantú

as Bernardo Félix Flores

Iker Madrid

as Ernesto Alonso

Sandra Echeverría

as María Félix

Jeronimo Guerra

as Quique (adolescente)

Emiliano González

as Pablo 'Gato' Félix

Aida López

as Jana

Joshua Gutiérrez

as Pedro Armendáriz

Áxel Ricco

as Gabriel Figueroa

Ximena Ayala

as Frida Kahlo

Ramón Medína

as Emilio 'El indio' Fernández

Helena Rojo

as Señora Russek

Claudio Lafarga

as Enrique Álvarez

Rodrigo Magaña

as Agustín Lara

Enoc Leaño

as Diego Rivera

Ana Bertha Espín

as Señora Paz

Epy Vélez

as Bibi

David Caro Levy

as Enrique Álvarez Félix (joven)

Elsa Ortiz

as Dolores del Río