FOX 25th Anniversary Special

Ryan Seacrest

as Self - Host

Christina Applegate

as Self

Katey Sagal

as Self

Ed O'Neill

as Self

David Faustino

as Self

Seth MacFarlane

as Self

Evan Marriott

as Self

David Duchovny

as Self

Gillian Anderson

as Self

Chris Carter

as Self

Calista Flockhart

as Self

Kelsey Grammer

as Self

Katy Perry

as Self

Shannen Doherty

as Self

Gabrielle Carteris

as Self

Jason Priestley

as Self

Ian Ziering

as Self

Terry Bradshaw

as Self

Joe Buck

as Self

Hugh Laurie

as Self

Kiefer Sutherland

as Self

Carrie Underwood

as Self

Ashton Kutcher

as Self

Mila Kunis

as Self

Laura Prepon

as Self

Wilmer Valderrama

as Self

Keenen Ivory Wayans

as Self

Marlon Wayans

as Self

Tommy Davidson

as Self

Shawn Wayans

as Self

Dan Castellaneta

as Homer Simpson (voice) (uncredited)

Nancy Cartwright

as Bart Simpson (voice) (uncredited)

Julie Kavner

as Marge Simpson (voice) (uncredited)

Yeardley Smith

as Lisa Simpson (voice) (uncredited)

Zooey Deschanel

as Self (voice) (uncredited)

Hank Azaria

as Moe Szyslak (voice) (uncredited)

Mike Henry

as Cleveland Brown (voice) (uncredited)

Dan Mintz

as Tina Belcher (voice) (uncredited)

Eugene Mirman

as Gene Belcher (voice) (uncredited)

John Roberts

as Linda Belcher (voice) (uncredited)

H. Jon Benjamin

as Bob Belcher (voice) (uncredited)

Kristen Schaal

as Louise Belcher (voice) (uncredited)

Jim Carrey

as Self (archive footage) (uncredited)

Jennifer Lopez

as Self (archive footage) (uncredited)