Ang Agimat: Anting-anting ni Lolo

Ramon Revilla Sr.

as Matandang Ermitanyo

Ramon 'Bong' Revilla Jr.

as Paolo / Enteng / Matandang Ketongin

Jolo Revilla

as Pao

Mylene Dizon

as Aling Virgie / Manananggal

Carlos Morales

as Ancient Evil

Shaina Magdayao

as Jayra

Nancy Castiglione

as Queen Evil

Jaime Fabregas

as Dr. Reliquia

Pen Medina

as Fr. Tolon

Goyong

as Pao-Pao

Karylle

as Maryang Makiling

Gina Alajar

as Clarita

Patrick Dela Rosa

as Gorgo

Lester Llansang

as Atoy

Katarina Perez

as Classmate / Victim

Coco Martin

as Armon

Tristan Nepomuceno

as Borgi

R.U. Miranda

as Classmate

Pola Salvador

as Classmate

Krizzie Martinez

as Classmate

Luz Imperial

as High School Principal

Tina Cascarro

as Secretary of Principal

Colleen Bautista

as Classmate

Crystal Revilla

as Classmate